Том 21 № 2
ОБЗОРЫ

Плейотропные эффекты левосимендана на сердце и другие органы

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  • В. Ломиворотов,
  • В. Бобошко
В. Ломиворотов
ФГБУ «Сибирский федеральный биомедицинский исследовательский центр имени академика Е.Н. Мешалкина», Министерство здравоохранения Российской Федерации, Новосибирск, Российская Федерация
В. Бобошко
ФГБУ «Сибирский федеральный биомедицинский исследовательский центр имени академика Е.Н. Мешалкина», Министерство здравоохранения Российской Федерации, Новосибирск, Российская Федерация
Bio
DOI: https://doi.org/10.21688/1681-3472-2017-2-14-28

Опубликован 10.07.2017

Ключевые слова

  • левосимендан,
  • плейотропные эффекты,
  • кардиотонические препараты,
  • сердечная недостаточность,
  • инфаркт миокарда,
  • кардиогенный шок,
  • кардиопротекция,
  • органопротекция
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Как цитировать

Ломиворотов, В., & Бобошко, В. (2017). Плейотропные эффекты левосимендана на сердце и другие органы. Патология кровообращения и кардиохирургия, 21(2), 14–28. https://doi.org/10.21688/1681-3472-2017-2-14-28

Copyright (c) 2017 Ломиворотов В.В., Бобошко В.А.

Лицензия Creative Commons

Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.

Аннотация

Левосимендан — негликозидное кардиотоническое лекарственное средство, обладающее вазодилатирующими свойствами. К основным механизмам действия препарата относят увеличение чувствительности сократительных белков кардиомиоцитов к кальцию и способность открывать аденозинтрифосфат-зависимые калиевые каналы в гладких мышцах сосудистой стенки. В соответствии с настоящими рекомендациями Европейского общества кардиологов, показанием к использованию левосимендана является лечение острой декомпенсации тяжелой хронической сердечной недостаточности. С момента первого применения препарата (более 15 лет назад) обнаружен ряд дополнительных плейотропных эффектов, которые не только оказывают влияние на состояние миокарда (при ишемии и ремоделировании), но и потенцируют органопротективные процессы за пределами сердечно-сосудистой системы. В ходе экспериментальных и клинических исследований были выявлены механизмы, оказывающие положительное влияние на функцию легких, почек, печени, органов желудочно-кишечного тракта, центральной нервной системы, а также на процессы воспаления и сепсиса. В данной обзорной статье обобщены существующие исследования и доказательства плейотропных эффектов левосимендана, а также показаны потенциальные новые области его клинического применения.

Поступила в редакцию 3 апреля 2017 г. Принята к печати 30 мая 2016 г.

Финансирование
Исследование не имело спонсорской поддержки.
Конфликт интересов
Авторы заявляют об отсутствии конфликта интересов.

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